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PRORP-PSMA6 PRORP-PSMA6 readthrough [ Homo sapiens (human) ]

Gene ID: 127814298, updated on 10-Oct-2023

Summary

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Gene symbol
PRORP-PSMA6
Gene description
PRORP-PSMA6 readthrough
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring readthrough transcription between the neighboring PRORP (protein only RNase P catalytic subunit) and PSMA6 (proteasome 20S subunit alpha 6) genes on chromosome 14. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Nov 2022]
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Genomic context

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See PRORP-PSMA6 in Genome Data Viewer
Location:
14q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35121839..35317471)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (29318793..29505091)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35451517-35452218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8259 Neighboring gene signal recognition particle 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8262 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:35571935-35572102 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:35581755-35582536 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:35590400-35591599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35591739-35592658 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35622091-35622592 Neighboring gene Sharpr-MPRA regulatory region 10139 Neighboring gene ribosomal protein L23a pseudogene 70 Neighboring gene protein only RNase P catalytic subunit Neighboring gene septin 7 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 8 Neighboring gene divergent-paired related homeobox pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35761289-35761875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8272 Neighboring gene ribosomal protein L9 pseudogene 3 Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene Sharpr-MPRA regulatory region 8744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35801329-35802250 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:35802261-35802870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35805755-35806276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:35811147-35812003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35816286-35816830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35836533-35837122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:35837123-35837710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:35837711-35838299 Neighboring gene CRISPRi-validated cis-regulatory element chr14.550 Neighboring gene Sharpr-MPRA regulatory region 4470 Neighboring gene PSMA6-RPLP0P3 intergenic CAGE-defined low expression enhancer Neighboring gene Sharpr-MPRA regulatory region 12595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:35871323-35872196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35873941-35874812 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 3 Neighboring gene NFKB inhibitor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_182666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121594, AL133163

  2. NR_182667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121594, AL133163

  3. NR_182668.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121594, AL133163

  4. NR_182669.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121594, AL133163

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    35121839..35317471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    29318793..29505091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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