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LOC127814804 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66833587-66834422 [ Homo sapiens (human) ]

Gene ID: 127814804, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127814804
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66833587-66834422
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127814804 in Genome Data Viewer
Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (40880559..40881394)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (42413799..42414634, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (66833587..66834422)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 49 pseudogene Neighboring gene ankyrin repeat domain 30B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28422 Neighboring gene RNA, U6 small nuclear 156, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr9:66768055-66768556 Neighboring gene NANOG hESC enhancer GRCh37_chr9:66784324-66784825 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:66809156-66809719 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:66818900-66819484 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:66823139-66823953 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66832750-66833586 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66834423-66835258 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:66843600-66844341 Neighboring gene NANOG hESC enhancer GRCh37_chr9:66854522-66855023 Neighboring gene MPRA-validated peak7256 silencer Neighboring gene uncharacterized LOC107986997 Neighboring gene microRNA 1299 Neighboring gene NANOG hESC enhancer GRCh37_chr9:68695497-68695998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:69048303-69048804 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:68712489-68713157 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:68725219-68725948

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_116324.1 

    Range
    101..936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    40880559..40881394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    42413799..42414634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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