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LOC127817393 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22042835-22043494 [ Homo sapiens (human) ]

Gene ID: 127817393, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127817393
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22042835-22043494
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127817393 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (21753906..21754565)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (21772980..21773639)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22042835..22043494)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MLLT10 histone lysine methyltransferase DOT1L cofactor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21952461-21953111 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:21954039-21954538 Neighboring gene Sharpr-MPRA regulatory region 7684 Neighboring gene RNA, U6 small nuclear 1141, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:21999974-22000474 Neighboring gene NANOG hESC enhancer GRCh37_chr10:22015451-22015952 Neighboring gene uncharacterized LOC107984214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:22036939-22037438 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:22039902-22041101 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22041514-22042174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22043495-22044154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22045403-22046279 Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:22085326-22085864 Neighboring gene RN7SK pseudogene 219 Neighboring gene Sharpr-MPRA regulatory region 11860 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:22099351-22100550 Neighboring gene MPRA-validated peak900 silencer Neighboring gene MPRA-validated peak901 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr10:22157554-22158082 Neighboring gene MPRA-validated peak902 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22220654-22221154 Neighboring gene RN7SK pseudogene 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_118873.1 

    Range
    101..760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    21753906..21754565
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    21772980..21773639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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