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LOC127817595 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:35751643-35752185 [ Homo sapiens (human) ]

Gene ID: 127817595, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127817595
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:35751643-35752185
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127817595 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35462715..35463257)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35491318..35491860)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35751643..35752185)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene Sharpr-MPRA regulatory region 12265 Neighboring gene CCNY antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2305 Neighboring gene Sharpr-MPRA regulatory region 1021 Neighboring gene Sharpr-MPRA regulatory region 675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2306 Neighboring gene uncharacterized LOC124902410 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:35736957-35737627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2307 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:35751098-35751642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:35752610-35753110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3265 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:35806272-35806772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:35806773-35807273 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:35819404-35820603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3268 Neighboring gene uncharacterized LOC107984221 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:35883203-35883845 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35889926-35890176 Neighboring gene gap junction protein delta 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_119075.1 

    Range
    101..643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    35462715..35463257
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    35491318..35491860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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