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LOC127818100 H3K4me1 hESC enhancer GRCh37_chr10:64576972-64577969 [ Homo sapiens (human) ]

Gene ID: 127818100, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127818100
Gene description
H3K4me1 hESC enhancer GRCh37_chr10:64576972-64577969
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K4me1 histone modification. This locus also includes two accessible chromatin subregions, one of which was validated as an enhancer and the other as a silencer based on their ability to activate or repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127818100 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (62817212..62818246)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (63675354..63676388)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (64576972..64578006)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3432 Neighboring gene 2-aminoethanethiol dioxygenase Neighboring gene early growth response 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3433 Neighboring gene uncharacterized LOC107984012 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:64684239-64684456 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_13913 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_14056 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_14069 Neighboring gene MPRA-validated peak959 silencer Neighboring gene RNA, U6 small nuclear 543, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 3431
  • ATAC-STARR-seq lymphoblastoid silent region 2403

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_119574.2 

    Range
    101..1135
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    62817212..62818246
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    63675354..63676388
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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