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LOC127818402 NANOG-H3K27ac hESC enhancer GRCh37_chr10:76983719-76984474 [ Homo sapiens (human) ]

Gene ID: 127818402, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127818402
Gene description
NANOG-H3K27ac hESC enhancer GRCh37_chr10:76983719-76984474
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127818402 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75223961..75224716)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (76097451..76098206)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76983719..76984474)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76898750-76898917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76901445-76901944 Neighboring gene MPRA-validated peak1024 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76966815-76967564 Neighboring gene Sharpr-MPRA regulatory region 10124 Neighboring gene Sharpr-MPRA regulatory region 7934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76982209-76982964 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76985985-76986738 Neighboring gene voltage dependent anion channel 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2513 Neighboring gene Sharpr-MPRA regulatory region 13796 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene VISTA enhancer hs1437 Neighboring gene ribosomal protein L39 pseudogene 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_119875.1 

    Range
    101..856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    75223961..75224716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    76097451..76098206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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