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LOC127818851 H3K4me1 hESC enhancer GRCh37_chr10:98460100-98460600 [ Homo sapiens (human) ]

Gene ID: 127818851, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127818851
Gene description
H3K4me1 hESC enhancer GRCh37_chr10:98460100-98460600
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K4me1 histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127818851 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (96700343..96700843)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (97581497..97581997)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase adaptor protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:98382174-98382395 Neighboring gene RNA, 5S ribosomal pseudogene 324 Neighboring gene ribosomal protein S2 pseudogene 36 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3840 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:98493035-98493740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:98494688-98495484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3842 Neighboring gene RNA, U6 small nuclear 1274, pseudogene Neighboring gene ribosomal protein L13a pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 3835

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_120323.1 

    Range
    101..601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    96700343..96700843
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    97581497..97581997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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