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LOC127819203 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112313795-112314372 [ Homo sapiens (human) ]

Gene ID: 127819203, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127819203
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112313795-112314372
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127819203 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (110554037..110554614)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (111437827..111438404)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112313795..112314372)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4030 Neighboring gene dual specificity phosphatase 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4033 Neighboring gene Sharpr-MPRA regulatory region 14569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4036 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112313217-112313794 Neighboring gene ribosomal protein L7 pseudogene 35 Neighboring gene uncharacterized LOC105378483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112325756-112326458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2820 Neighboring gene small nucleolar RNA U13 Neighboring gene structural maintenance of chromosomes 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_120674.1 

    Range
    101..678
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    110554037..110554614
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    111437827..111438404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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