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LOC127819319 H3K27ac hESC enhancer GRCh37_chr10:120101641-120102140 [ Homo sapiens (human) ]

Gene ID: 127819319, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127819319
Gene description
H3K27ac hESC enhancer GRCh37_chr10:120101641-120102140
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (118342129..118342628)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119237116..119237615)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2863 Neighboring gene cancer susceptibility 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119907111-119907355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119963650-119964234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119964235-119964819 Neighboring gene Sharpr-MPRA regulatory region 3281 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:119973305-119974504 Neighboring gene long intergenic non-protein coding RNA 2944 Neighboring gene NANOG hESC enhancer GRCh37_chr10:120025545-120026208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120044911-120045412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120045413-120045912 Neighboring gene VISTA enhancer hs672 Neighboring gene family with sequence similarity 204 member A Neighboring gene long intergenic non-protein coding RNA 867 Neighboring gene Sharpr-MPRA regulatory region 4791 Neighboring gene uncharacterized LOC105378507

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 4102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_120790.1 

    Range
    101..600
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    118342129..118342628
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    119237116..119237615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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