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LOC127820363 H3K4me1 hESC enhancer GRCh37_chr11:9116861-9117362 [ Homo sapiens (human) ]

Gene ID: 127820363, updated on 12-Sep-2024

Summary

Gene symbol
LOC127820363
Gene description
H3K4me1 hESC enhancer GRCh37_chr11:9116861-9117362
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. An accessible chromatin subregion was used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. That subregion was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Jun 2023]
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Genomic context

See LOC127820363 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9095314..9095815)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9180087..9180588)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9116861..9117362)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9024725-9025644 Neighboring gene nuclear receptor interacting protein 3 Neighboring gene NRIP3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3119 Neighboring gene signal peptide, CUB domain and EGF like domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9068585-9069086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9087649-9088150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9088151-9088650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9117363-9117862 Neighboring gene microRNA 5691 Neighboring gene uncharacterized LOC105376542 Neighboring gene keratin 8 pseudogene 41 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9142475-9143138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4401 Neighboring gene Sharpr-MPRA regulatory region 9656 Neighboring gene DENN domain containing 5A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:9190693-9191892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9250779-9251379 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9251982-9252582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9273812-9274511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3123

Genomic regions, transcripts, and products

General gene information

Other Names

  • ReSE screen-validated silencer GRCh37_chr11:9116954-9117159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_121822.1 

    Range
    101..602
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9095314..9095815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9180087..9180588
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    GenBank, FASTA, Sequence Viewer (Graphics)