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LOC127820371 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9339994-9340970 [ Homo sapiens (human) ]

Gene ID: 127820371, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127820371
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9339994-9340970
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is regulatory element in the vicinity of coronavirus related gene(s).
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Genomic context

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See LOC127820371 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9318447..9319423)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9403588..9404564)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9339994..9340970)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene transmembrane protein 41B Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9335331-9335848 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9335849-9336364 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:9340971-9341947 Neighboring gene proline rich 13 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9372391-9372892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9376493-9376993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377088-9377646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377647-9378203 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:9385258-9386457 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9406201-9406716 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:9420900-9421065 Neighboring gene importin 7 Neighboring gene Sharpr-MPRA regulatory region 11606 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9480928-9481563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4408 Neighboring gene ZNF143 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_121830.1 

    Range
    101..1077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9318447..9319423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9403588..9404564
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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