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LOC127820775 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36310336-36311038 [ Homo sapiens (human) ]

Gene ID: 127820775, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127820775
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36310336-36311038
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (36288786..36289574)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (36429129..36429917)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36310336..36311124)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:36039319-36040518 Neighboring gene Sharpr-MPRA regulatory region 260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:36060221-36060728 Neighboring gene microRNA 3973 Neighboring gene uncharacterized LOC101928510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36111937-36112464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36112465-36112991 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21313 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36127161-36128105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36128106-36129049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:36129695-36130220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36130221-36130744 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36131269-36131792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36132843-36133366 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36165205-36165812 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:36170828-36172027 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21355 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:36200889-36201107 Neighboring gene Sharpr-MPRA regulatory region 9208 Neighboring gene Sharpr-MPRA regulatory region 15199 Neighboring gene COMM domain containing 9 Neighboring gene proline rich 5 like Neighboring gene Sharpr-MPRA regulatory region 5372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:36398745-36399316 Neighboring gene Sharpr-MPRA regulatory region 14138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36476801-36477325 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:36522348-36523547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4633 Neighboring gene TNF receptor associated factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 4631

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_122234.2 

    Range
    101..889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    36288786..36289574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    36429129..36429917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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