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LOC127821118 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58938742-58939282 [ Homo sapiens (human) ]

Gene ID: 127821118, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127821118
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58938742-58939282
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127821118 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59171269..59171809)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59120444..59120984)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58938742..58939282)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FAM111A divergent transcript Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4747 Neighboring gene FAM111 trypsin like peptidase A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4749 Neighboring gene basic proline-rich protein-like Neighboring gene Sharpr-MPRA regulatory region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58940291-58941119 Neighboring gene uncharacterized LOC124902675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3362 Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3363 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:58967822-58969021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4753 Neighboring gene macrophage expressed 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_122575.1 

    Range
    101..641
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    59171269..59171809
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    59120444..59120984
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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