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LOC127821594 H3K27ac hESC enhancer GRCh37_chr11:66867665-66868165 [ Homo sapiens (human) ]

Gene ID: 127821594, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127821594
Gene description
H3K27ac hESC enhancer GRCh37_chr11:66867665-66868165
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127821594 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67100194..67100694)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67091863..67092363)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66867665..66868165)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene synaptotagmin 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66816246-66816774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3610 Neighboring gene microRNA 6860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66841392-66841892 Neighboring gene MPRA-validated peak1310 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66845407-66846302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5068 Neighboring gene ras homolog family member D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5070 Neighboring gene uncharacterized LOC107984341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3618 Neighboring gene uncharacterized LOC124902695 Neighboring gene lysine demethylase 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 5071

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_123043.1 

    Range
    101..601
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67100194..67100694
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67091863..67092363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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