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LOC127823572 H3K27ac hESC enhancer GRCh37_chr12:7846215-7846852 [ Homo sapiens (human) ]

Gene ID: 127823572, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127823572
Gene description
H3K27ac hESC enhancer GRCh37_chr12:7846215-7846852
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127823572 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7693619..7694256)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7708385..7709022)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7846215..7846852)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene clathrin light chain A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7761225-7761725 Neighboring gene MPRA-validated peak1559 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:7790442-7790976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4203 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 1 Neighboring gene Sharpr-MPRA regulatory region 10898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7824935-7825436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7825437-7825936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7856907-7857580 Neighboring gene growth differentiation factor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7860307-7860932 Neighboring gene developmental pluripotency associated 3 Neighboring gene MPRA-validated peak1561 silencer Neighboring gene C-type lectin domain family 4 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_125093.1 

    Range
    101..738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7693619..7694256
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7708385..7709022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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