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LOC127824606 NANOG hESC enhancer GRCh37_chr12:77358407-77359020 [ Homo sapiens (human) ]

Gene ID: 127824606, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127824606
Gene description
NANOG hESC enhancer GRCh37_chr12:77358407-77359020
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127824606 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (76964627..76965240)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (76942460..76943073)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77358407..77359020)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77158059-77158901 Neighboring gene zinc finger DHHC-type palmitoyltransferase 17 Neighboring gene MPRA-validated peak1846 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4673 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77268223-77268724 Neighboring gene uncharacterized LOC124902971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4675 Neighboring gene cysteine and glycine rich protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77313616-77314124 Neighboring gene Sharpr-MPRA regulatory region 9474 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:77329846-77331045 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:77425832-77427031 Neighboring gene E2F transcription factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4676 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:77459297-77460003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126122.1 

    Range
    101..714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    76964627..76965240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    76942460..76943073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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