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LOC127824831 H3K27ac hESC enhancer GRCh37_chr12:100536197-100536960 [ Homo sapiens (human) ]

Gene ID: 127824831, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127824831
Gene description
H3K27ac hESC enhancer GRCh37_chr12:100536197-100536960
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes two accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127824831 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (100142289..100143182)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (100103524..100104417)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (100536067..100536960)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:100064333-100064865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:100074143-100074643 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:100117017-100117569 Neighboring gene golgi associated RAB2 interactor family member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100377744-100378574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4760 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:100414790-100414953 Neighboring gene ribosomal protein S4X pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100551036-100551924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100550146-100551035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100546825-100547326 Neighboring gene NANOG hESC enhancer GRCh37_chr12:100540373-100541181 Neighboring gene bridge-like lipid transfer protein family member 3B Neighboring gene BLTP3B divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 176, pseudogene Neighboring gene GOLGA2 pseudogene 5 Neighboring gene dynamin 1 pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 4762
  • ATAC-STARR-seq lymphoblastoid silent region 4763

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126347.2 

    Range
    101..994
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    100142289..100143182
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    100103524..100104417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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