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LOC127826156 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:41254046-41254810 [ Homo sapiens (human) ]

Gene ID: 127826156, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127826156
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:41254046-41254810
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127826156 in Genome Data Viewer
Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (40679909..40680673)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (39898888..39899652)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41254046..41254810)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 598 Neighboring gene RN7SK pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41019797-41020402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5279 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:41092118-41093317 Neighboring gene Sharpr-MPRA regulatory region 6999 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:41114319-41114868 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:41114869-41115418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41115419-41115966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:41119870-41120370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:41120371-41120871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41137465-41138218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7610 Neighboring gene forkhead box O1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7612 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41225852-41226373 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41226374-41226894 Neighboring gene ring finger protein, LIM domain interacting pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7613 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41254811-41255575 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41255576-41256340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41286412-41286912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41308619-41309202 Neighboring gene microRNA 320d-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7614 Neighboring gene mitochondrial ribosomal protein S31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_127663.1 

    Range
    101..865
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    40679909..40680673
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    39898888..39899652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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