U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127827571 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:52117631-52118249 [ Homo sapiens (human) ]

Gene ID: 127827571, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC127827571
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:52117631-52118249
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127827571 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (51650913..51651573)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (45857825..45858485)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene FERM domain containing 6 Neighboring gene FRMD6 antisense RNA 2 Neighboring gene RNA, U6 small nuclear 1291, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:52000910-52002109 Neighboring gene uncharacterized LOC124903415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5740 Neighboring gene FRMD6 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 385 Neighboring gene RNA, U6 small nuclear 301, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 5736

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_129074.2 

    Range
    101..761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    51650913..51651573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    45857825..45858485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases