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LOC127828988 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:24932126-24932730 [ Homo sapiens (human) ]

Gene ID: 127828988, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127828988
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:24932126-24932730
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127828988 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24686979..24687583)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (22422641..22423245)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (24932126..24932730)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr15:24877390-24877896 Neighboring gene Prader-Willi region non-protein coding RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24941505-24942052 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:24942053-24942599 Neighboring gene nuclear pore associated protein 1 Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:25017418-25018314 and GRCh37_chr15:25018315-25019210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25101506-25102019 Neighboring gene Sharpr-MPRA regulatory region 849 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25103559-25104072 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25104073-25104585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25107499-25108228 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA host gene 14 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:25143773-25144405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:25145037-25145537 Neighboring gene small nuclear ribonucleoprotein polypeptide N Neighboring gene ribosomal protein L5 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_130484.1 

    Range
    101..705
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    24686979..24687583
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    22422641..22423245
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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