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ARL8A ARF like GTPase 8A [ Homo sapiens (human) ]

Gene ID: 127829, updated on 2-Nov-2024

Summary

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Official Symbol
ARL8Aprovided by HGNC
Official Full Name
ARF like GTPase 8Aprovided by HGNC
Primary source
HGNC:HGNC:25192
See related
Ensembl:ENSG00000143862 MIM:616597; AllianceGenome:HGNC:25192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIE2; ARL10B
Summary
Enables GTP binding activity. Predicted to be involved in anterograde axonal transport and chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ARL8A in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (202133404..202144737, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (201390975..201402296, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202102532..202113865, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371684 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:202072166-202073140 Neighboring gene cysteine rich protein 1 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202073141-202074115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202077042-202078015 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10703 Neighboring gene uncharacterized LOC105371683 Neighboring gene G protein-coupled receptor 37 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202099011-202099794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202099795-202100578 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:202104477-202104684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1698 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1699 Neighboring gene protein tyrosine phosphatase non-receptor type 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202132551-202133219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202133799-202134299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202134943-202135522 Neighboring gene protein tyrosine phosphatase receptor type V, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202152613-202153112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202153807-202154336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202154337-202154866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. Hofmann I, et al. J Cell Sci, 2006 Apr 15. PMID 16537643
  2. Exploration of panviral proteome: high-throughput cloning and functional implications in virus-host interactions. Yu X, et al. Theranostics, 2014. PMID 24955142, Free PMC Article
  3. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. Okai T, et al. J Cell Sci, 2004 Sep 15. PMID 15331635
  4. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. Marwaha R, et al. J Cell Biol, 2017 Apr 3. PMID 28325809, Free PMC Article
  5. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein. Secombe J, et al. J Biol Chem, 2004 Apr 23. PMID 14871887

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane HDA PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 8A
Names
ADP ribosylation factor like GTPase 8A
ADP-ribosylation factor-like 10B
ADP-ribosylation factor-like 8A
GTPase indispensable for equal segregation of chromosomes 2
novel small G protein indispensable for equal chromosome segregation 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256129.2 → NP_001243058.1  ADP-ribosylation factor-like protein 8A isoform 2

    See identical proteins and their annotated locations for NP_001243058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK127138, AW090198, BC069053, BG876867, BP325806
    Consensus CDS
    CCDS73004.1
    UniProtKB/TrEMBL
    A0A087X2J2
    Related
    ENSP00000485023.1, ENST00000614750.1
    Conserved Domains (1) summary
    cd04159
    Location:22 → 128
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

  2. NM_138795.4 → NP_620150.1  ADP-ribosylation factor-like protein 8A isoform 1

    See identical proteins and their annotated locations for NP_620150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW090198, BC015408, BC069053, BP325806
    Consensus CDS
    CCDS1421.1
    UniProtKB/Swiss-Prot
    B3KXD0, Q96BM9
    UniProtKB/TrEMBL
    B2R7U5
    Related
    ENSP00000272217.2, ENST00000272217.7
    Conserved Domains (1) summary
    cd04159
    Location:22 → 180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    202133404..202144737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    201390975..201402296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BM9.1 GenPept UniProtKB/Swiss-Prot:Q96BM9

Gene LinkOut

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