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LOC127829955 OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:68944208-68944708 [ Homo sapiens (human) ]

Gene ID: 127829955, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127829955
Gene description
OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:68944208-68944708
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K4me1 histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127829955 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68651869..68652369)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66474741..66475241)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68944208..68944708)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903513 Neighboring gene uncharacterized LOC105370873 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:68799611-68800181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68810923-68811424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68811425-68811924 Neighboring gene coronin 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68842985-68843486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68871520-68872387 Neighboring gene Sharpr-MPRA regulatory region 3237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68882548-68883339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68892023-68892602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68893807-68894366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68900721-68901361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68906675-68907190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68933009-68933520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68933521-68934032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68934266-68934783 Neighboring gene uncharacterized LOC124903514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68943583-68944150 Neighboring gene Sharpr-MPRA regulatory region 8573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68961677-68962176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68966278-68966778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68987247-68987836 Neighboring gene heart enhancer 11 Neighboring gene cysteinyl-tRNA synthetase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69080134-69080641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69083767-69084268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69084269-69084768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69087559-69088131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9650 Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene microRNA 4312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_131437.1 

    Range
    101..601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    68651869..68652369
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    66474741..66475241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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