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LOC127882651 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 [ Homo sapiens (human) ]

Gene ID: 127882651, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127882651
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes two accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127882651 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (649400..650224)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (653468..654292)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (699400..700224)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene WD repeat domain 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene ras homolog family member T2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:724963-725497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 6933
  • ATAC-STARR-seq lymphoblastoid silent region 6934

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_132618.2 

    Range
    101..925
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    649400..650224
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    653468..654292
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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