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LOC127884889 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85644485-85645006 [ Homo sapiens (human) ]

Gene ID: 127884889, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127884889
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85644485-85645006
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, Jun 2023]
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Genomic context

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See LOC127884889 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (85610832..85611400)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (91676047..91676615)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Gse1 coiled-coil protein Neighboring gene uncharacterized LOC124903738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7806 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:85485239-85485738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85485752-85486252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85491854-85492505 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:85493140-85493848 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85493849-85494555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85494556-85495263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85496679-85497386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85498095-85498800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85507767-85508622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85508623-85509477 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:85522312-85522482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85523747-85524594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85524595-85525442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85525443-85526290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85547643-85548327 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85548328-85549011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85549012-85549696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85549697-85550379 Neighboring gene uncharacterized LOC124903739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85557842-85558457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85559689-85560304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85558458-85559072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85575513-85576422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85578183-85579016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85580527-85581027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85583771-85584359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85584360-85584947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7808 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:85588705-85589205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85590477-85591335 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:85592721-85592911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85598712-85599441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85600901-85601628 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:85601775-85601970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85610162-85610728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85611294-85611859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85613556-85614120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85616579-85617188 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85617189-85617800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85617801-85618411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85618412-85619022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85619023-85619633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85621594-85622550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85623933-85624848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85632946-85633646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85634349-85635068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85635069-85635787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85635788-85636506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85638229-85638872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85645007-85645528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85647861-85648712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85652369-85653040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85653041-85653712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85658570-85659078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85659079-85659586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85660691-85661510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85660095-85660601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85661511-85662329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85665311-85666088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85668961-85669914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85672914-85673448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85673449-85673981 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85685005-85685906 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:85704698-85704871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85721369-85721902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7817 Neighboring gene RNA, 7SL, cytoplasmic 381, pseudogene Neighboring gene GINS complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 11278
  • ATAC-STARR-seq lymphoblastoid active region 11279

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_134647.2 

    Range
    101..669
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    85610832..85611400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    91676047..91676615
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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