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LOC127888675 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4125481-4126460 [ Homo sapiens (human) ]

Gene ID: 127888675, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127888675
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4125481-4126460
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (4125481..4126460)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (4285431..4286410)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene DLG associated protein 1 Neighboring gene DLGAP1 antisense RNA 3 Neighboring gene RNA, U6 small nuclear 831, pseudogene Neighboring gene DLGAP1 antisense RNA 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:4017491-4018172 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 66 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4117736-4118323 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4118324-4118910 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4119078-4119849 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4124501-4125480 Neighboring gene uncharacterized LOC124904239 Neighboring gene Sharpr-MPRA regulatory region 11006 Neighboring gene NANOG hESC enhancer GRCh37_chr18:4195745-4196246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47861 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4233399-4234316 Neighboring gene DLGAP1 antisense RNA 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138259.1 

    Range
    101..1080
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    4125481..4126460
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    4285431..4286410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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