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LOC127889267 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46308177-46308808 [ Homo sapiens (human) ]

Gene ID: 127889267, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127889267
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46308177-46308808
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (48781806..48782437)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (48977090..48977721)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene cap binding complex dependent translation initiation factor Neighboring gene uncharacterized LOC105372107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46202169-46202793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46225014-46225804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46225805-46226594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46283862-46284450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46284451-46285039 Neighboring gene uncharacterized LOC107985147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46302432-46302932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46302933-46303433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46304669-46305610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46305651-46306282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46306915-46307546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13295 Neighboring gene uncharacterized LOC105372106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13298 Neighboring gene uncharacterized LOC105372105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46359045-46359708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46362171-46363071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46363072-46363971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46364242-46365020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46365021-46365799

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138805.1 

    Range
    101..732
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    48781806..48782437
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171814.1 Reference GRCh38.p14 PATCHES

    Range
    271076..271707
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    48977090..48977721
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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