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LOC127889270 H3K4me1 hESC enhancer GRCh37_chr18:46364242-46365020 [ Homo sapiens (human) ]

Gene ID: 127889270, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127889270
Gene description
H3K4me1 hESC enhancer GRCh37_chr18:46364242-46365020
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K4me1 histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127889270 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (48837871..48838649)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49033171..49033949)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene cap binding complex dependent translation initiation factor Neighboring gene uncharacterized LOC107985147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46302933-46303433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46302432-46302932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46304669-46305610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46305651-46306282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46306915-46307546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46308177-46308808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13295 Neighboring gene uncharacterized LOC105372106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13298 Neighboring gene uncharacterized LOC105372105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46359045-46359708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46362171-46363071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46363072-46363971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46365021-46365799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46370909-46371409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46384077-46384578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46388739-46389290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13301 Neighboring gene Sharpr-MPRA regulatory region 12870 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:46404101-46404331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46419523-46420032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46420541-46421048 Neighboring gene Sharpr-MPRA regulatory region 7610 Neighboring gene uncharacterized LOC124904355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46449409-46450340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46452405-46453366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46459221-46460106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9439 Neighboring gene NANOG hESC enhancer GRCh37_chr18:46474665-46475166 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:46468263-46469462 Neighboring gene SMAD family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138808.1 

    Range
    101..879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    48837871..48838649
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171814.1 Reference GRCh38.p14 PATCHES

    Range
    327141..327919
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49033171..49033949
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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