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LOC127889304 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47138971-47139847 [ Homo sapiens (human) ]

Gene ID: 127889304, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127889304
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47138971-47139847
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127889304 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (49612601..49613477)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49810419..49811295)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47138971..47139847)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:47026295-47027190 Neighboring gene long intergenic non-protein coding RNA 2837 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:47042044-47042658 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:47057605-47057776 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:47076971-47078170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47088634-47089134 Neighboring gene lipase G, endothelial type Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:47135425-47136624 Neighboring gene uncharacterized LOC105372112 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47139848-47140723 Neighboring gene MPRA-validated peak3145 silencer Neighboring gene uncharacterized LOC112268210 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:47185307-47185916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47189661-47190508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47190509-47191354 Neighboring gene single-strand-selective monofunctional uracil-DNA glycosylase 1 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:47249700-47250899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47252155-47252900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47252901-47253644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47283654-47284603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47285800-47286402 Neighboring gene Sharpr-MPRA regulatory region 2051 Neighboring gene acetyl-CoA acyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138840.1 

    Range
    101..977
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    49612601..49613477
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49810419..49811295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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