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LOC127889445 H3K27ac hESC enhancer GRCh37_chr18:56557049-56557549 [ Homo sapiens (human) ]

Gene ID: 127889445, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127889445
Gene description
H3K27ac hESC enhancer GRCh37_chr18:56557049-56557549
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (58889817..58890317)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (59091079..59091579)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1397 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56475059-56476049 Neighboring gene RNA, U6 small nuclear 219, pseudogene Neighboring gene U8 small nucleolar RNA Neighboring gene long intergenic non-protein coding RNA 1926 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56513039-56513851 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56513852-56514664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56514665-56515477 Neighboring gene Sharpr-MPRA regulatory region 466 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:56529025-56529566 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56529567-56530106 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56537205-56538186 Neighboring gene zinc finger protein 532 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56556548-56557048 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:56559638-56560464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56582766-56583276 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56635193-56636106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56650842-56652041 Neighboring gene O-acyltransferase like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56716067-56717037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56717038-56718007 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56729547-56730746

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138974.1 

    Range
    101..601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    58889817..58890317
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    59091079..59091579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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