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LOC127889748 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:77720052-77720736 [ Homo sapiens (human) ]

Gene ID: 127889748, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127889748
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:77720052-77720736
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (79960052..79960736)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (80236576..80237260)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:77664167-77664802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:77672372-77673288 Neighboring gene solute carrier family 66 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9583 Neighboring gene uncharacterized LOC124904336 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:77717730-77718328 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:77718329-77718926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9584 Neighboring gene heat shock factor binding protein 1 like 1 Neighboring gene thioredoxin like 4A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9586 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:77762974-77763187 Neighboring gene OCT4 hESC enhancer GRCh37_chr18:77766658-77767159 Neighboring gene Sharpr-MPRA regulatory region 15651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9587 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:77793921-77794077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9590 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:77808538-77809737 Neighboring gene ribosome binding factor A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_139262.1 

    Range
    101..785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    79960052..79960736
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    80236576..80237260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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