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LOC127891352 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622 [ Homo sapiens (human) ]

Gene ID: 127891352, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127891352
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127891352 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36246732..36247720)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38795147..38796135)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36646245-36646976 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678024-36678563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678564-36679102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36683570-36684070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36684071-36684571 Neighboring gene zinc finger protein 565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14521 Neighboring gene zinc finger protein 146 Neighboring gene uncharacterized LOC107985304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724474-36724976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724977-36725478 Neighboring gene MPRA-validated peak3458 silencer Neighboring gene MPRA-validated peak3459 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36735657-36736645 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36736677-36736900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36748697-36749315 Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene uncharacterized LOC100134317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_141223.1 

    Range
    101..1089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36246732..36247720
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38795147..38796135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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