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LOC127892521 OCT4-NANOG hESC enhancer GRCh37_chr20:4244845-4245360 [ Homo sapiens (human) ]

Gene ID: 127892521, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127892521
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr20:4244845-4245360
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (4264198..4264713)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (4298583..4299098)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:4175883-4176064 Neighboring gene MPRA-validated peak4129 silencer Neighboring gene long intergenic non-protein coding RNA 1433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4197441-4198178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:4202467-4202967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4212957-4213457 Neighboring gene Sharpr-MPRA regulatory region 5115 Neighboring gene adrenoceptor alpha 1D Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:4306716-4307915 Neighboring gene uncharacterized LOC124904862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4501639-4502140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4502141-4502640 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:4526897-4527638 Neighboring gene uncharacterized LOC105372510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_142324.1 

    Range
    101..616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    4264198..4264713
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    4298583..4299098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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