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LOC127893500 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45974595-45975341 [ Homo sapiens (human) ]

Gene ID: 127893500, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127893500
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45974595-45975341
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127893500 in Genome Data Viewer
Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47345851..47346597)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49084131..49084877)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45974595..45975341)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene Sharpr-MPRA regulatory region 12423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17980 Neighboring gene microRNA 3616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45836841-45837466 Neighboring gene Sharpr-MPRA regulatory region 5760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45837467-45838090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45863077-45863577 Neighboring gene zinc finger MYND-type containing 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45881941-45882441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45904588-45905088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45905089-45905589 Neighboring gene Sharpr-MPRA regulatory region 15539 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:45945484-45946683 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45947067-45947983 Neighboring gene uncharacterized LOC100131496 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45947984-45948902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45950739-45951656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45957753-45958400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45959988-45960488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45964446-45965285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45965286-45966124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45968129-45968628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45971039-45971820 Neighboring gene uncharacterized LOC101927377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45983444-45984051 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45985267-45985874 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45986483-45987088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:45987089-45987696 and GRCh37_chr20:45987697-45988304 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46001472-46002090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46004693-46005194 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46005195-46005694 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46007335-46007835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46012139-46012991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17992 Neighboring gene long intergenic non-protein coding RNA 1754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_143225.1 

    Range
    101..847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    47345851..47346597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    49084131..49084877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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