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Cnn1 calponin 1 [ Mus musculus (house mouse) ]

Gene ID: 12797, updated on 28-Oct-2024

Summary

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Official Symbol
Cnn1provided by MGI
Official Full Name
calponin 1provided by MGI
Primary source
MGI:MGI:104979
See related
Ensembl:ENSMUSG00000001349 AllianceGenome:MGI:104979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CN; CnnI
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system gland; and lung. Orthologous to human CNN1 (calponin 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in bladder adult (RPKM 1016.2), colon adult (RPKM 481.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cnn1 in Genome Data Viewer
Location:
9 A3; 9 8.3 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22010501..22020517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22099221..22109221)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16845 Neighboring gene ECSIT signalling integrator Neighboring gene STARR-positive B cell enhancer ABC_E8280 Neighboring gene predicted gene 6581 Neighboring gene STARR-positive B cell enhancer ABC_E2285 Neighboring gene STARR-positive B cell enhancer ABC_E11403 Neighboring gene microRNA 7084 Neighboring gene ELF1 homolog, elongation factor 1 Neighboring gene acid phosphatase 5, tartrate resistant

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation. Su N, et al. J Bone Miner Res, 2013 Mar. PMID 23044709, Free PMC Article
  2. The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy. Pfuhl M, et al. Biophys J, 2011 Apr 6. PMID 21463585, Free PMC Article
  3. Loss of smooth muscle calponin results in impaired blood vessel maturation in the tumor-host microenvironment. Yamamura H, et al. Cancer Sci, 2007 May. PMID 17391313, Free PMC Article
  4. Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin knockout mice. Masuki S, et al. J Physiol, 2003 Nov 15. PMID 12963798, Free PMC Article
  5. Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice. Bannai M, et al. J Vet Med Sci, 2003 Jan. PMID 12576725

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.
    Title: Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.
  2. Cnn1(-/-) and Cnn2(-/-) double knockout aortic smooth muscle exhibits faster relaxation than that of wild type control.
    Title: Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle.
  3. Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
    Title: Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
  4. These findings reveal a novel function of CNN1 in maintaining bone homeostasis by coupling bone formation to bone resorption
    Title: Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation.
  5. data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility.
    Title: Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor.
  6. A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation.
    Title: Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.
  7. The structure of this functionally important region of calponin and its interaction with actin and calmodulin at amino-acid resolution, was mapped.
    Title: The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy.
  8. Mutated mice showed increased locomotor activity, as well as increased intake of food and water, associated with the decreased number of neurons in the paraventricular nucleus of the hypothalamus (PVN)
    Title: Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice.
  9. Up-regulation of h1-calponin in SM-B null mice may be necessary to maintain reduced level of cross-bridge cycling over time in absence of SM-B myosin and play important role in regulating smooth muscle contraction.
    Title: Effects of h1-calponin ablation on the contractile properties of bladder versus vascular smooth muscle in mice lacking SM-B myosin.
  10. CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility
    Title: Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
calponin-1
Names
basic calponin
calponin H1, smooth muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009922.4 → NP_034052.3  calponin-1

    See identical proteins and their annotated locations for NP_034052.3

    Status: VALIDATED

    Source sequence(s)
    AK035548, BY326336
    Consensus CDS
    CCDS22921.1
    UniProtKB/Swiss-Prot
    Q08091
    UniProtKB/TrEMBL
    B2RSH3, Q8CBQ2
    Related
    ENSMUSP00000001384.5, ENSMUST00000001384.6
    Conserved Domains (3) summary
    COG5199
    Location:18 → 188
    SCP1; Calponin [Cytoskeleton]
    pfam00307
    Location:29 → 127
    CH; Calponin homology (CH) domain
    pfam00402
    Location:164 → 187
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22010501..22020517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242388.3 → XP_011240690.2  calponin-1 isoform X1

    UniProtKB/TrEMBL
    Q8CBQ2
    Conserved Domains (2) summary
    pfam00402
    Location:213 → 237
    Calponin; Calponin family repeat
    cd21282
    Location:76 → 183
    CH_CNN1; calponin homology (CH) domain found in calponin-1 and similar proteins

  2. XM_006509969.3 → XP_006510032.1  calponin-1 isoform X2

    See identical proteins and their annotated locations for XP_006510032.1

    UniProtKB/TrEMBL
    A0A1L1SUB2
    Related
    ENSMUSP00000150665.2, ENSMUST00000216872.2
    Conserved Domains (2) summary
    COG5199
    Location:1 → 138
    SCP1; Calponin [Cytoskeleton]
    pfam00402
    Location:154 → 177
    Calponin; Calponin family repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08091.1 GenPept UniProtKB/Swiss-Prot:Q08091

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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