Cnn2 calponin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnn2provided by MGI
Official Full Name: calponin 2provided by MGI
Primary source: MGI:MGI:105093
See related: Ensembl:ENSMUSG00000004665 AllianceGenome:MGI:105093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Calpo2
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including negative regulation of macrophage migration; negative regulation of phagocytosis; and regulation of mononuclear cell proliferation. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including 4-cell stage embryo; central nervous system; eye; forelimb; and lateral plate mesoderm. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 223.3), spleen adult (RPKM 194.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79824434..79831234)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79988600..79995400)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Calponin 2 causes premature ovarian insufficiency in mice.
Title: Loss of Calponin 2 causes premature ovarian insufficiency in mice.
Calponin 2 regulates ketogenesis to mitigate acute kidney injury.
Title: Calponin 2 regulates ketogenesis to mitigate acute kidney injury.
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis.
Title: Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis.
Loss of Calponin 2 causes age-progressive proteinuria in mice.
Title: Loss of Calponin 2 causes age-progressive proteinuria in mice.
Deletion of Calponin 2 Reduces the Formation of Postoperative Peritoneal Adhesions.
Title: Deletion of Calponin 2 Reduces the Formation of Postoperative Peritoneal Adhesions.
A rapid degradation of calponin 2 is required for cytokinesis.
Title: A rapid degradation of calponin 2 is required for cytokinesis.
Cnn1(-/-) and Cnn2(-/-) double knockout aortic smooth muscle exhibits faster relaxation than that of wild type control.
Title: Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle.
Cnn2 KO attenuated TGFb1-induced differentiation of myofibroblasts in culture as shown by the lower expression of SMA and less calcification than that of wild type (WT) cells. These findings present calponin 2 as a novel molecular target for the treatment and prevention of Calcific aortic valve
Title: Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE(-/-) mice.
Calponin 2-null macrophages and foam cells have significantly weakened cell adhesion, indicating a role of cytoskeleton regulation in macrophage functions and inflammatory responses, and a novel therapeutic target for the treatment of arterial atherosclerosis.
Title: Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis.
The novel finding that calponin 2 regulates myosin-dependent CTF in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions
Title: Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cnn2 (e-PCR), detects polymorphism
- UniSTS:498466

Z19543 (e-PCR)
- UniSTS:163481

RH125760 (e-PCR)
- UniSTS:162512

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin filament-based process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of leukocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mononuclear cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: calponin-2

Names: calponin H2, smooth muscle; h2-calponin; neutral calponin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.