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LOC128316696 NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:144931414-144932162 and GRCh37_chr1:144932163-144932912 [ Homo sapiens (human) ]

Gene ID: 128316696, updated on 12-Sep-2024

Summary

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Gene symbol
LOC128316696
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:144931414-144932162 and GRCh37_chr1:144932163-144932912
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes two adjacent enhancers that were validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where both enhancers associate with the NANOG transcription factor and are marked by the H3K27ac and H3K4me1 histone modifications. An overlapping subregion represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. That subregion was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC128316696 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (148951577..148953075)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145618379..145619866)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (144931414..144932912, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D interacting protein Neighboring gene uncharacterized LOC112268272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145015143-145015643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144994512-144995132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144993892-144994511 Neighboring gene NANOG hESC enhancer GRCh37_chr1:144976465-144977040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144966957-144967786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:144961997-144962606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144937763-144938539 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:144936334-144936835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144932913-144933661 Neighboring gene RNA, U2 small nuclear 38, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:144891435-144892634 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:144867459-144868658 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144850469-144850968 Neighboring gene NBPF member 9 Neighboring gene profilin-1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1288 Neighboring gene uncharacterized LOC101929790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  3. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 1651
  • NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144931414-144932162
  • NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144932163-144932912
  • ReSE screen-validated silencer GRCh37_chr1:144931955-144932243

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_149300.2 

    Range
    101..1599
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    148951577..148953075
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    145618379..145619866
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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