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NKAIN4 sodium/potassium transporting ATPase interacting 4 [ Homo sapiens (human) ]

Gene ID: 128414, updated on 3-Apr-2024

Summary

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Official Symbol
NKAIN4provided by HGNC
Official Full Name
sodium/potassium transporting ATPase interacting 4provided by HGNC
Primary source
HGNC:HGNC:16191
See related
Ensembl:ENSG00000101198 MIM:612873; AllianceGenome:HGNC:16191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM77A; C20orf58; bA261N11.2
Summary
NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in brain (RPKM 15.5), kidney (RPKM 2.4) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
20q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63240784..63254921, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65046799..65060428, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61872136..61885815, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61830673-61831272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61831273-61831874 Neighboring gene YTH N6-methyladenosine RNA binding protein F1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61857740-61858694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61862252-61863021 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:61863095-61864294 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61865058-61865253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61866073-61866674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61870596-61871096 Neighboring gene uncharacterized LOC124904950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61879175-61880007 Neighboring gene microRNA 3196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61880008-61880839 Neighboring gene baculoviral IAP repeat containing 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61883491-61883999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61885071-61885602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61885603-61886134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61889508-61890125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61891361-61891976 Neighboring gene uncharacterized LOC100192386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13151 Neighboring gene ADP ribosylation factor GTPase activating protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61915538-61916038 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr20:61922048-61922671 and GRCh37_chr20:61922672-61923296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61924431-61924932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61924933-61925432 Neighboring gene microRNA 4326 Neighboring gene collagen type XX alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61952290-61952790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  2. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
Na+/K+ transporting ATPase interacting 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363718.1 → NP_001350647.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK126246, AL121827, BI918324, BJ991175, BM673598, HY107676
    Consensus CDS
    CCDS86967.1
    UniProtKB/TrEMBL
    J3JS66
    Related
    ENSP00000359336.1, ENST00000370313.5
    Conserved Domains (1) summary
    pfam05640
    Location:1 → 115
    NKAIN; Na,K-Atpase Interacting protein

  2. NM_001363747.1 → NP_001350676.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK126246, AL121827, BM673598, BP219020, HY107676
    Consensus CDS
    CCDS86968.1
    UniProtKB/TrEMBL
    A6NNM2
    Conserved Domains (1) summary
    pfam05640
    Location:1 → 144
    NKAIN; Na,K-Atpase Interacting protein

  3. NM_152864.4 → NP_690603.3  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_690603.3

    Status: VALIDATED

    Source sequence(s)
    AK126246, BG708360, BM673598
    Consensus CDS
    CCDS13514.1
    UniProtKB/Swiss-Prot
    Q4VXQ6, Q8IVV8, Q9BQU8, Q9BQU9
    UniProtKB/TrEMBL
    B3KWY5
    Related
    ENSP00000359340.3, ENST00000370316.8
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 206
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63240784..63254921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027636.3 → XP_016883125.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 143
    NKAIN; Na,K-Atpase Interacting protein

  2. XM_047439871.1 → XP_047295827.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

    UniProtKB/TrEMBL
    A6NNM2
    Related
    ENSP00000359330.2, ENST00000370307.6

  3. XM_047439872.1 → XP_047295828.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

  4. XM_005260192.3 → XP_005260249.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

    See identical proteins and their annotated locations for XP_005260249.1

    UniProtKB/TrEMBL
    B3KWY5
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 177
    NKAIN; Na,K-Atpase Interacting protein

  5. XM_011528527.3 → XP_011526829.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

    UniProtKB/TrEMBL
    B3KWY5
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 205
    NKAIN; Na,K-Atpase Interacting protein

  6. XM_011528529.4 → XP_011526831.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011526831.1

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 143
    NKAIN; Na,K-Atpase Interacting protein

  7. XM_017027637.3 → XP_016883126.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 143
    NKAIN; Na,K-Atpase Interacting protein

  8. XM_011528528.4 → XP_011526830.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011526830.1

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 143
    NKAIN; Na,K-Atpase Interacting protein

  9. XM_024451824.2 → XP_024307592.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05640
    Location:1 → 143
    NKAIN; Na,K-Atpase Interacting protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65046799..65060428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322939.1 → XP_054178914.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

  2. XM_054322938.1 → XP_054178913.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

  3. XM_054322940.1 → XP_054178915.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVV8.2 GenPept UniProtKB/Swiss-Prot:Q8IVV8

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