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LOC128462391 CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81250836-81251336 [ Homo sapiens (human) ]

Gene ID: 128462391, updated on 10-Oct-2023

Summary

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Gene symbol
LOC128462391
Gene description
CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81250836-81251336
Gene type
biological region
Feature type(s)
regulatory: transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be an enhancer based on an activity-by-contact (ABC) model that predicts enhancer-gene connections, where the putative enhancer strength is measured by DNase I hypersensitivity and H3K27 acetylation, and the contact frequency by Hi-C. It was validated as a positively-acting cis-regulatory element for the PPIF (peptidylprolyl isomerase F) gene based on CRISPR/Cas9-mediated perturbation (CRISPRi-FlowFISH method) in BJAB lymphoma cells. [provided by RefSeq, Feb 2023]
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Genomic context

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See LOC128462391 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (79491080..79491580)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (80360189..80360689)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81145819-81146746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81150060-81150645 Neighboring gene zinc finger CCHC-type containing 24 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81159191-81159691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81162702-81163510 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81163946-81164446 and GRCh37_chr10:81163953-81164453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81165127-81165934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81172654-81173164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81173165-81173673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81184235-81184736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81194851-81195489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2542 Neighboring gene uncharacterized LOC105378383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3647 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:81257847-81258047 Neighboring gene tetrapeptide repeat homeobox 1 pseudogene 1 Neighboring gene uncharacterized LOC729815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide enhancer maps link risk variants to disease genes. Nasser J, et al. Nature, 2021 May. PMID 33828297, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_149579.1 

    Range
    101..601
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    79491080..79491580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    80360189..80360689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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