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Cplx2 complexin 2 [ Mus musculus (house mouse) ]

Gene ID: 12890, updated on 2-Nov-2024

Summary

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Official Symbol
Cplx2provided by MGI
Official Full Name
complexin 2provided by MGI
Primary source
MGI:MGI:104726
See related
Ensembl:ENSMUSG00000025867 Ensembl:ENSMUSG00000112941 AllianceGenome:MGI:104726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
921-L; Gm34843
Summary
Predicted to enable calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in positive regulation of synaptic plasticity and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Is active in calyx of Held and glutamatergic synapse. Is expressed in nervous system; retina layer; and skeletal muscle. Used to study schizophrenia. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 102.7), frontal lobe adult (RPKM 85.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cplx2 in Genome Data Viewer
Location:
13 B1; 13 28.59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54455447..54531736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54301964..54383923)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene histamine receptor H2 Neighboring gene predicted gene 16578 Neighboring gene predicted gene, 40955 Neighboring gene predicted gene, 48622 Neighboring gene STARR-positive B cell enhancer ABC_E5398 Neighboring gene STARR-positive B cell enhancer ABC_E11782 Neighboring gene STARR-positive B cell enhancer ABC_E7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54548428-54548615 Neighboring gene STARR-positive B cell enhancer ABC_E10794 Neighboring gene THO complex 3 Neighboring gene predicted gene, 53205 Neighboring gene predicted gene 2830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse. Gibson HE, et al. Eur J Neurosci, 2005 Oct. PMID 16197510
  2. [Effects of neonatal isolation stress on hyperlocomotion of complexin II knockout mouse]. Yu H, et al. Sheng Li Xue Bao, 2011 Aug 25. PMID 21861047
  3. Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Glynn D, et al. Hum Mol Genet, 2010 Sep 1. PMID 20584925
  4. Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia. Radyushkin K, et al. Genes Brain Behav, 2010 Aug. PMID 20412316
  5. Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Cai H, et al. Proc Natl Acad Sci U S A, 2008 Dec 9. PMID 19033464, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic beta cell function.
    Title: Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
  2. Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25.
    Title: Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25.
  3. data suggest that CPLX2 inhibits spontaneous secretion of IgM and IgG1 from splenic antibody-secreting cells (ASCs). This study provides new insight into the mechanism of antibody secretion of ASCs.
    Title: Complexin 2 regulates secretion of immunoglobulin in antibody-secreting cells.
  4. the C2B domain of syt1, independent of complexin, is the molecular clamp that arrests synaptic vesicles prior to Ca(2+)-triggered fusion.
    Title: Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
  5. We describe a high degree of structural similarity between the CpxII CTD and the SNAP25-SN1 domain (C-terminal half) and show that the CTD peptide lowers the rate of SDS-resistant SNARE complex formation in vitro. Moreover, corresponding CpxII:SNAP25 chimeras do restore complexin's function and even 'superclamp' tonic secretion.
    Title: A mechanism for exocytotic arrest by the Complexin C-terminus.
  6. Complexin II is a central target molecule that links NADPH oxidase-derived reactive oxygen species to glutamate-mediated neuronal excitotoxicity in ischemic stroke.
    Title: NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke.
  7. CpxII attenuates fluctuations of the early fusion pore and slows its expansion.
    Title: Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.
  8. Cplx 1 and 2 play a role in facilitating vesicle priming, and also lead to the new hypothesis that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels.
    Title: Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems.
  9. Cplx2 knockout mice exhibit hyperlocomotion following neonatal isolation stress.
    Title: [Effects of neonatal isolation stress on hyperlocomotion of complexin II knockout mouse].
  10. Several months after lesion, Cplx2 null mutants showed reduced pre-pulse inhibition, deficit of spatial learning and loss of inhibition after MK-801 challenge.
    Title: Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
Inferred from Electronic Annotation
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
complexin-2
Names
CPX II
complexin II
synaphin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362218.1 → NP_001349147.1  complexin-2

    Status: VALIDATED

    Source sequence(s)
    AC242674, AW492120, CJ108367, CX240169
    Consensus CDS
    CCDS36667.1
    UniProtKB/Swiss-Prot
    P84086, Q32KK4
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

  2. NM_009946.3 → NP_034076.1  complexin-2

    See identical proteins and their annotated locations for NP_034076.1

    Status: VALIDATED

    Source sequence(s)
    AC242674, BN000502
    Consensus CDS
    CCDS36667.1
    UniProtKB/Swiss-Prot
    P84086, Q32KK4
    Related
    ENSMUSP00000026985.9, ENSMUST00000026985.9
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

RNA

  1. NR_155492.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BE984504, BM941693, CJ108367, CX240169
    Related
    ENSMUST00000240905.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54455447..54531736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315376.3 → XP_017170865.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84086, Q32KK4
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84086.1 GenPept UniProtKB/Swiss-Prot:P84086

Gene LinkOut

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