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Crybb1 crystallin, beta B1 [ Mus musculus (house mouse) ]

Gene ID: 12960, updated on 2-Nov-2024

Summary

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Official Symbol
Crybb1provided by MGI
Official Full Name
crystallin, beta B1provided by MGI
Primary source
MGI:MGI:104992
See related
Ensembl:ENSMUSG00000029343 AllianceGenome:MGI:104992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB1CRY; 3110006K12Rik
Summary
This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in genital fat pad adult (RPKM 1.8), ovary adult (RPKM 1.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Crybb1 in Genome Data Viewer
Location:
5 F; 5 54.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112403686..112417451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112254563..112269585)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene myocardial infarction associated transcript (non-protein coding) Neighboring gene VISTA enhancer mm1451 Neighboring gene predicted gene, 52821 Neighboring gene crystallin, beta A4 Neighboring gene STARR-positive B cell enhancer ABC_E6365 Neighboring gene STARR-positive B cell enhancer ABC_E6366 Neighboring gene STARR-positive B cell enhancer ABC_E1685 Neighboring gene predicted gene, 46941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:112714594-112714795 Neighboring gene protein-tyrosine sulfotransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental regulation of the chicken beta B1-crystallin promoter in transgenic mice. Duncan MK, et al. Mech Dev, 1996 Jun. PMID 8817455
  2. The mouse beta B1-crystallin promoter: strict regulation of lens fiber cell specificity. Chen WV, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406268
  3. Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice. Spadaro PA, et al. Biol Psychiatry, 2015 Dec 15. PMID 25792222, Free PMC Article
  4. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Dolinska MB, et al. Biochemistry, 2009 Oct 13. PMID 19746987, Free PMC Article
  5. BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen. Stempel D, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506076

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation.
    Title: Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers.
  2. Removal of the N-terminal extension of beta B1-crystallin has major effects on the physical properties of the protein by increasing the self-association potential and by blocking heteromolecular associations with beta A3-crystallin.
    Title: N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin.
  3. mixed betaB1- and betaA3-crystallins associate predominantly into heterotetramers in equilibrium with heterodimers
    Title: Association properties of betaB1- and betaA3-crystallins: ability to form heterotetramers.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of eye lens ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in eye development IEA
Inferred from Electronic Annotation
more info
  
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-crystallin B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312893.1 → NP_001299822.1  beta-crystallin B1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
    Source sequence(s)
    AK014012, CA452040, CX767595
    Consensus CDS
    CCDS19537.1
    UniProtKB/Swiss-Prot
    Q9WVJ5
    UniProtKB/TrEMBL
    E9PYP8
    Conserved Domains (1) summary
    pfam00030
    Location:148 → 230
    Crystall; Beta/Gamma crystallin

  2. NM_001312894.1 → NP_001299823.1  beta-crystallin B1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 - 4 encodes the same protein.
    Source sequence(s)
    AC123795, AK014012, CA452040, CO046108
    Consensus CDS
    CCDS19537.1
    UniProtKB/Swiss-Prot
    Q9WVJ5
    UniProtKB/TrEMBL
    E9PYP8
    Related
    ENSMUSP00000118399.2, ENSMUST00000131673.8
    Conserved Domains (1) summary
    pfam00030
    Location:148 → 230
    Crystall; Beta/Gamma crystallin

  3. NM_001312895.1 → NP_001299824.1  beta-crystallin B1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
    Source sequence(s)
    AC123795, CX767799, CX767857
    Consensus CDS
    CCDS19537.1
    UniProtKB/Swiss-Prot
    Q9WVJ5
    UniProtKB/TrEMBL
    E9PYP8
    Related
    ENSMUSP00000107994.2, ENSMUST00000112375.2
    Conserved Domains (1) summary
    pfam00030
    Location:148 → 230
    Crystall; Beta/Gamma crystallin

  4. NM_023695.3 → NP_076184.1  beta-crystallin B1

    See identical proteins and their annotated locations for NP_076184.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
    Source sequence(s)
    AK014012, CA452040
    Consensus CDS
    CCDS19537.1
    UniProtKB/Swiss-Prot
    Q9WVJ5
    UniProtKB/TrEMBL
    E9PYP8
    Related
    ENSMUSP00000031286.7, ENSMUST00000031286.13
    Conserved Domains (1) summary
    pfam00030
    Location:148 → 230
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    112403686..112417451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534754.5 → XP_006534817.1  beta-crystallin B1 isoform X1

    UniProtKB/TrEMBL
    E9PYP8
    Conserved Domains (1) summary
    pfam00030
    Location:166 → 248
    Crystall; Beta/Gamma crystallin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVJ5.3 GenPept UniProtKB/Swiss-Prot:Q9WVJ5

Gene LinkOut

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