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LOC129660454 ReSE screen-validated silencer GRCh37_chr1:201591323-201591707 [ Homo sapiens (human) ]

Gene ID: 129660454, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129660454
Gene description
ReSE screen-validated silencer GRCh37_chr1:201591323-201591707
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129660454 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201622195..201622579)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200879983..200880367)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201591323..201591707)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1692 Neighboring gene uncharacterized LOC124904484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2321 Neighboring gene cysteine and glycine rich protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201487479-201487990 Neighboring gene CSRP1 antisense RNA 1 Neighboring gene ribosomal protein S10 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201534809-201535310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201535311-201535810 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10615 Neighboring gene neuron navigator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201560646-201561209 Neighboring gene uncharacterized LOC124904482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201597565-201598066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201653379-201653880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201653881-201654380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201659372-201659872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201672490-201673062 Neighboring gene IPO9 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201688752-201689398 Neighboring gene uncharacterized LOC124904483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:201693607-201694108 Neighboring gene microRNA 5191 Neighboring gene RNA, U6 small nuclear 501, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157491.1 

    Range
    101..485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    201622195..201622579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    200879983..200880367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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