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LOC129662394 ReSE screen-validated silencer GRCh37_chr8:142379063-142379245 [ Homo sapiens (human) ]

Gene ID: 129662394, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129662394
Gene description
ReSE screen-validated silencer GRCh37_chr8:142379063-142379245
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129662394 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141368963..141369145)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142490415..142490597)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142379063..142379245)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142352272-142352772 Neighboring gene long intergenic non-protein coding RNA 1300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142355946-142356566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142361861-142362840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142366583-142367204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142367205-142367826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142369677-142370273 Neighboring gene G protein-coupled receptor 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142378149-142378698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142382601-142383224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142383225-142383848 Neighboring gene uncharacterized LOC101928037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385104-142385878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142385879-142386654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142386655-142387429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142394223-142394840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142401193-142401813 Neighboring gene antisense transcript of PTP4A3, liver carcinoma survival associated Neighboring gene protein tyrosine phosphatase 4A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_159421.1 

    Range
    101..283
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141368963..141369145
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791786.1 Reference GRCh38.p14 PATCHES

    Range
    35517..35699
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187574.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    35517..35699
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142490415..142490597
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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