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LOC129662753 ReSE screen-validated silencer GRCh37_chr10:79596052-79596324 [ Homo sapiens (human) ]

Gene ID: 129662753, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129662753
Gene description
ReSE screen-validated silencer GRCh37_chr10:79596052-79596324
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129662753 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (77836294..77836566)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (78705355..78705627)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79596052..79596324)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1266, pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 5 Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79568517-79569016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79591709-79592210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79592211-79592710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79596746-79597366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79601269-79601770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79613571-79614072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79614073-79614572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616089-79616612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616613-79617136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79623439-79624198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79625716-79626473 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79627013-79628212 Neighboring gene Sharpr-MPRA regulatory region 8551 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79637563-79638502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79649557-79650232 Neighboring gene uncharacterized LOC101929347 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79651583-79652256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79660915-79661442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79661443-79661970 Neighboring gene Sharpr-MPRA regulatory region 4447 Neighboring gene NFE2L2 motif-containing MPRA enhancers 69 and 123 Neighboring gene RNA, 7SL, cytoplasmic 284, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_159761.1 

    Range
    101..373
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    77836294..77836566
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    78705355..78705627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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