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LOC129662768 ReSE screen-validated silencer GRCh37_chr10:88288988-88289146 [ Homo sapiens (human) ]

Gene ID: 129662768, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129662768
Gene description
ReSE screen-validated silencer GRCh37_chr10:88288988-88289146
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in both phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) and untreated K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129662768 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (86529231..86529389)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (87413425..87413583)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88288988..88289146)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene WAPL cohesin release factor Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88263469-88263969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2570 Neighboring gene WAPL divergent transcript Neighboring gene uncharacterized LOC105378408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88295813-88296362 Neighboring gene uncharacterized LOC105378407 Neighboring gene uncharacterized LOC105378406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_159776.1 

    Range
    101..259
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    86529231..86529389
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    87413425..87413583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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