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LOC129663509 ReSE screen-validated silencer GRCh37_chr14:103213106-103213279 [ Homo sapiens (human) ]

Gene ID: 129663509, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663509
Gene description
ReSE screen-validated silencer GRCh37_chr14:103213106-103213279
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663509 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102746769..102746942)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96983118..96983291)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103213106..103213279)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103050544-103051072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103057589-103058404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6127 Neighboring gene RNA, 7SL, cytoplasmic 546, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9076 Neighboring gene REST corepressor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:103119605-103120104 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103129073-103129810 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103188411-103189610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103204471-103204972 Neighboring gene uncharacterized LOC124903390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103216089-103216923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103224133-103224633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103236826-103237330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103237331-103237835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6131 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103249335-103249487 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9085 Neighboring gene TNF receptor associated factor 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103276021-103276180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103294403-103294902 Neighboring gene NANOG hESC enhancer GRCh37_chr14:103307110-103307650 Neighboring gene RNA, U6 small nuclear 1316, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160515.1 

    Range
    101..274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102746769..102746942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96983118..96983291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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