U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC129663803 ReSE screen-validated silencer GRCh37_chr16:30681557-30681750 [ Homo sapiens (human) ]

Gene ID: 129663803, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC129663803
Gene description
ReSE screen-validated silencer GRCh37_chr16:30681557-30681750
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC129663803 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30670236..30670429)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31057207..31057400)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30681557..30681750)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7388 Neighboring gene proline rich 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10718 Neighboring gene fibrosin Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30688172-30689072 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689073-30689972 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689973-30690873 Neighboring gene RNA, U6 small nuclear 416, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30693026-30693526 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30697048-30697206 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:30705076-30705670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7389 Neighboring gene Sharpr-MPRA regulatory region 39 Neighboring gene uncharacterized LOC730183

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160809.1 

    Range
    101..294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30670236..30670429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31057207..31057400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases