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LOC129664779 ReSE screen-validated silencer GRCh37_chr22:19799088-19799263 [ Homo sapiens (human) ]

Gene ID: 129664779, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129664779
Gene description
ReSE screen-validated silencer GRCh37_chr22:19799088-19799263
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129664779 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (19811565..19811740)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20188435..20188610)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19799088..19799263)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19744621-19745499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19745779-19746288 Neighboring gene VISTA enhancer hs515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19750215-19751157 Neighboring gene T-box transcription factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19758419-19758590 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19764062-19764563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19771036-19771536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19771537-19772037 Neighboring gene G protein subunit beta 1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19784762-19785467 Neighboring gene ribosomal protein L7a pseudogene 70 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19786734-19787315 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19794010-19794254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19810945-19811459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19831532-19832045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19832046-19832558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19832559-19833071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19840887-19841505 Neighboring gene uncharacterized LOC124905080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18663 Neighboring gene retrotransposon Gag like 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_161816.1 

    Range
    101..276
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    19811565..19811740
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20188435..20188610
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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