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Ctsg cathepsin G [ Mus musculus (house mouse) ]

Gene ID: 13035, updated on 4-Jan-2025

Summary

Official Symbol
Ctsgprovided by MGI
Official Full Name
cathepsin Gprovided by MGI
Primary source
MGI:MGI:88563
See related
Ensembl:ENSMUSG00000040314 AllianceGenome:MGI:88563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VSP; CatG
Summary
This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015]
Expression
Biased expression in liver E18 (RPKM 25.7), liver E14 (RPKM 22.2) and 1 other tissue See more
Orthologs
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Genomic context

See Ctsg in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56337342..56340031, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56099885..56102574, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mast cell protease 4 Neighboring gene microRNA 6949 Neighboring gene mast cell protease 8 Neighboring gene STARR-seq mESC enhancer starr_36791 Neighboring gene granzyme E Neighboring gene granzyme D

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables caspase binding  
enables caspase binding  
enables heparin binding  
enables peptidase activity  
enables protein binding PubMed 
enables receptor ligand activity  
enables receptor ligand activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type peptidase activity  
Items 1 - 25 of 36
Process Evidence Code Pubs
involved_in antibacterial humoral response  
involved_in antibacterial humoral response  
involved_in biofilm matrix disassembly  
involved_in biofilm matrix disassembly  
involved_in cellular response to lipopolysaccharide  
involved_in cellular response to lipopolysaccharide  
involved_in defense response to Gram-negative bacterium  
involved_in defense response to Gram-negative bacterium  
acts_upstream_of_or_within defense response to Gram-positive bacterium PubMed 
involved_in defense response to Gram-positive bacterium  
involved_in defense response to Gram-positive bacterium  
acts_upstream_of_or_within defense response to fungus PubMed 
acts_upstream_of_or_within defense response to fungus PubMed 
involved_in monocyte chemotaxis  
involved_in monocyte chemotaxis  
involved_in negative regulation of T cell activation  
involved_in negative regulation of T cell activation  
involved_in neutrophil activation  
involved_in neutrophil activation  
acts_upstream_of_or_within neutrophil-mediated killing of gram-positive bacterium PubMed 
involved_in platelet activation  
involved_in platelet activation  
acts_upstream_of_or_within positive regulation of immune response PubMed 
acts_upstream_of_or_within positive regulation of immune response PubMed 
involved_in positive regulation of platelet aggregation  
involved_in positive regulation of platelet aggregation  
involved_in protein maturation  
involved_in protein phosphorylation  
involved_in protein processing  
involved_in protein processing  
acts_upstream_of_or_within proteolysis  
involved_in proteolysis  
involved_in proteolysis  
acts_upstream_of_or_within response to lipopolysaccharide PubMed 
acts_upstream_of_or_within response to lipopolysaccharide PubMed 
involved_in signal transduction  
Items 1 - 25 of 36
Component Evidence Code Pubs
located_in cytoplasmic stress granule  
located_in cytoplasmic stress granule  
located_in cytosol  
located_in cytosol  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in lysosome  
located_in lysosome  
located_in membrane  
located_in membrane  
located_in nucleus  
located_in nucleus  
located_in plasma membrane  
located_in plasma membrane  
located_in secretory granule  

General protein information

Preferred Names
cathepsin G
Names
vimentin-specific protease
NP_031826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007800.2NP_031826.1  cathepsin G preproprotein

    See identical proteins and their annotated locations for NP_031826.1

    Status: REVIEWED

    Source sequence(s)
    AC091783, BU755975, CJ056088
    Consensus CDS
    CCDS27142.1
    UniProtKB/Swiss-Prot
    P28293
    UniProtKB/TrEMBL
    Q059V7
    Related
    ENSMUSP00000015583.2, ENSMUST00000015583.2
    Conserved Domains (2) summary
    smart00020
    Location:20238
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:21241
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56337342..56340031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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