Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2c29provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 29provided by MGI
Primary source: MGI:MGI:103238
See related: Ensembl:ENSMUSG00000003053 AllianceGenome:MGI:103238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AHOH; Ah-2; Ahh-1; Cyp2c; AHOHase; P450-2C
Summary: Enables arachidonate 14,15-epoxygenase activity. Involved in arachidonate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; carcinoma (multiple); end stage renal disease; glucose metabolism disease (multiple); and hypertension (multiple). Orthologous to several human genes including CYP2C18 (cytochrome P450 family 2 subfamily C member 18); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward liver adult (RPKM 514.1) See more
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Genomic context

Location:: 19 C3; 19 33.91 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (39275541..39319157)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (39287044..39330713)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.
Title: Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.
Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage.
Title: Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage.
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
Title: Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
Gene-targeted knockdown of CYP2C55, the homologous gene of CYP2C9, demonstrated viability rescue to light-induced cell death, whereas stable expression of functional CYP2C9-GFP fusion protein further exacerbated light-induced cell death.
Title: Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.
CYP2C29 synthesizes EETs to mediate SSID, and simultaneously releases superoxide and sequential H(2)O(2), which in turn impair SSID.
Title: CYP2C29 produces superoxide in response to shear stress.
Report role of CYP2c29/CYP4a in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
Title: Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
Midlozam metabolism in Cyp3a knockout mice can be attributed to up-regulated Cyp2c enzymes.
Title: Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI159681 (e-PCR)
- UniSTS:160831

Cyp2c29 (e-PCR), detects polymorphism
- UniSTS:462991

AI196010 (e-PCR)
- UniSTS:181232

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2C29

Names: CYPIIC29; aldehyde oxygenase; cytochrome P-450 MUT-2; cytochrome P450, 2c29

NP_001397082.1

EC 1.14.14.1

NP_031841.3

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.