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Dbp D site albumin promoter binding protein [ Mus musculus (house mouse) ]

Gene ID: 13170, updated on 2-Nov-2024

Summary

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Official Symbol
Dbpprovided by MGI
Official Full Name
D site albumin promoter binding proteinprovided by MGI
Primary source
MGI:MGI:94866
See related
Ensembl:ENSMUSG00000059824 AllianceGenome:MGI:94866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. [provided by RefSeq, Feb 2014]
Expression
Biased expression in adrenal adult (RPKM 215.0), bladder adult (RPKM 83.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Dbp in Genome Data Viewer
Location:
7 B3; 7 29.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45354658..45359579)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45705100..45710203)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene sphingosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger JA, et al. Genes Dev, 2000 Mar 15. PMID 10733528, Free PMC Article
  2. The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. Franken P, et al. J Neurosci, 2000 Jan 15. PMID 10632591, Free PMC Article
  3. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. Lopez-Molina L, et al. EMBO J, 1997 Nov 17. PMID 9362490, Free PMC Article
  4. The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. Kwon PK, et al. Mol Cell Biol, 2019 Aug 15. PMID 31160492, Free PMC Article
  5. Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction. Hamamura K, et al. J Biol Chem, 2016 Mar 4. PMID 26728457, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
    Title: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
  2. The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
    Title: The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
  3. Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.
    Title: Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.
  4. D-box-mediated transcriptional regulation plays pivotal roles in input and output in the circadian clock system.
    Title: Functional D-box sequences reset the circadian clock and drive mRNA rhythms.
  5. Study proposes that the poly(C) cis-acting element within the Dbp proximal promoter region supports the Dbp mRNA oscillation amplitude and sustains the mRNA oscillation level of Dbp-controlled clock genes.
    Title: The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.
  6. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK.
    Title: PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.
  7. constitutive Dbp expression plays an important role in mediating hepatic dysfunction under chronic kidney disease. DBP was significantly decreased in 5/6Nx model mice.
    Title: Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
  8. Dbp plays a well-established role in circadian rhythms.
    Title: Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation.
  9. Expressions of Dbp and Arnt were dampened in the islets of a diabetic model mouse.
    Title: Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells.
  10. BMAL1 and CLOCK may act as Kamikaze activators, in that they are rapidly degraded once bound to Dbp chromatin.
    Title: Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
D site-binding protein
Names
albumin D box-binding protein
albumin D-element-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412312.1 → NP_001399241.1  D site-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167242
    UniProtKB/TrEMBL
    A0A1B0GS46
    Related
    ENSMUSP00000147790.2, ENSMUST00000211513.2

  2. NM_001412313.1 → NP_001399242.1  D site-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167242
    UniProtKB/TrEMBL
    Q5XFZ5

  3. NM_016974.4 → NP_058670.2  D site-binding protein isoform 1

    See identical proteins and their annotated locations for NP_058670.2

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS21260.1
    UniProtKB/Swiss-Prot
    Q60925, Q8VCX3
    UniProtKB/TrEMBL
    Q3USN7
    Related
    ENSMUSP00000079693.4, ENSMUST00000080885.12
    Conserved Domains (1) summary
    cd14695
    Location:254 → 313
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45354658..45359579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540597.2 → XP_006540660.1  D site-binding protein isoform X2

    Conserved Domains (1) summary
    cd14695
    Location:117 → 176
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60925.2 GenPept UniProtKB/Swiss-Prot:Q60925

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